CLDN18.2 antibody design with protein language models: A deep learning optimization framework

Source: Plos.org· Tao Qu, Lingyan Yuan, Weiran Cui, Jiatian Tang, Zhitong Bing, Xianghong Xu, Jizheng Duan, Qiong Yang, Hui Cai· August 20, 2026
CLDN18.2 antibody design with protein language models: A deep learning optimization framework

Author summary Gastric cancer remains a major cause of cancer-related mortality worldwide, and effective treatment options are still limited for many patients. Claudin 18.2 (CLDN18.2) has emerged as a promising therapeutic target, as highlighted by the clinic…

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