Alignment-free prediction of cross-reactivity in influenza A (H3N2) anticipates antigenic drift

Source: Plos.org· Alpha Forna, Lambodhar Damodaran, Christian E. Gunning, Parnian Rahimi, Aarya Venkat, Natarajan Kannan, Rebecca Kondor, Justin Bahl, Pejman Rohani, John M. Drake· August 11, 2026

Author summary Influenza A (H3N2) viruses have evolved rapidly, necessitating frequent vaccine updates. Computational tools that can rapidly predict antigenic changes from sequence data alone could accelerate vaccine strain selection and reduce reliance on ti…

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