A public generalizable AI tool for automated segmentation of coronal brain tissue slabs for 3D neuropathology

Source: Plos.org· Jonathan Williams Ramirez, Dina Zemlyanker, Lucas Deden-Binder, Rogeny Herisse, Erendira Garcia Pallares, Karthik Gopinath, Harshvardhan Gazula, Christopher Mount, Liana N. Kozanno, Michael S. Marshall, Theresa R. Connors, Matthew P. Frosch, Mark Montine, Derek H. Oakley, Christine L. Mac Donald, C. Dirk Keene, Bradley T. Hyman, Bruce Fischl, Juan E. Iglesias· August 17, 2026
A public generalizable AI tool for automated segmentation of coronal brain tissue slabs for 3D neuropathology

Advances in image registration and machine learning have recently enabled volumetric analysis of postmortem brain tissue from conventional photographs of coronal slabs, which are routinely collected in brain banks and neuropathology laboratories around the wo…

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