DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants

Source: Plos.org· Jorge A. Acuña, Benjamin Gabriel, Kasirajan Ayyanathan, Jesse Miller, Yue Li, Kanupriya Whig, Yongqing Zhu, Marisa McGrath, Peter Hewins, Kellie Ann Jurado, Matthew B. Frieman, David C. Schultz, Sara Cherry· July 30, 2026
DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants

Author summary SARS-CoV-2 continues to spread in humans by evading innate and adaptive immune detection. Here, we compare the sensitivities of the ancestral WA1 and the Omicron BA.1 variant to a panel of innate immune agonists and find that short DNA oligonuc…

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