Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs
Source: Plos.org· Santosh Kumar Srivastava, Guo Wei Foo, Haosheng Shen, Yuanzhi He, Kwok Soon Wun, In Young Hwang, Michael S. Goodson, Nikhil Aggarwal, Matthew Wook Chang· August 25, 2026
Engineering microbial systems capable of sensing host-derived stress hormones has proved technically challenging. This study reconstitutes QseBC-mediated adrenergic sensing in Escherichia coli to create a catecholamine-responsive engineered probiotic strain c…
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