L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Source: Plos.org· Yuki Tamari, Rie Saba, Takushi Takata, Hiroyuki Kimura, Mao Takita, Kenta Yashiro, Minoru Suzuki, Hideya Yamazaki, Kei Yamada· August 13, 2026
L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Boron neutron capture therapy (BNCT) relies on the selective uptake of boron-10 compounds by tumor cells. L-boronophenylalanine (BPA) serves as a key carrier, and enhancing its accumulation is critical for improving BNCT efficacy. In this study, we examined h…

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