Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer
Source: Nature.com· Satoshi Shiba, Shinichi Yachida, Sayaka Mizutani, Yasushi Totoki, Hiromi Nakamura, Natsuko Hama, Norikatsu Miyoshi, Yasuhito Arai, Mihoko Saito-Adachi, Hirokazu Kimura, Yoshito Hayashi, Hiroyuki Takamaru, Koji Tanaka, Rie Hayashi, Hirofumi Rokutan, Shoko Ikuta, Yukihide Kanemitsu, Yuichiro Doki, Hidetoshi Eguchi, Satoshi Hattori, Yutaka Saito, Takuji Yamada, Tatsuhiro Shibata· August 10, 2026
Integrative analyses of whole-genome and transcriptome sequencing on Japanese colorectal cancer along with whole-genome metagenomic sequencing on fecal samples characterize host–microbiome interactions and colibactin-associated mutational signatures.
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