Quantitative modelling of P-TEFb mediated CTD phosphorylation identifies local cooperativity

Source: Plos.org· Aaron Callenbach, Domagoj Dorešić, Robert Düster, Vanessa Nakonecnij, Erika Dudkin, Matthias Geyer, Jan Hasenauer· July 30, 2026
Quantitative modelling of P-TEFb mediated CTD phosphorylation identifies local cooperativity

Author summary Gene expression in human cells is a carefully coordinated process that ensures the right genes are activated at the right time. Central to this process is RNA polymerase II, a multi-protein complex that transcribes DNA into precursors of messen…

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