Rationally designed minimized TbpB confers broad protection against meningococcal infection
Source: Plos.org· Epshita A. Islam, Jamie E. Fegan, Gregory B. Cole, Charles Calmettes, Dixon Ng, Natalie Y. T. Au, Carolyn M. Buckwalter, Sang K. Ahn, David M. Curran, Laura-lee Caruso, Anthony B. Schryvers, Trevor F. Moraes, Scott D. Gray-Owen· August 10, 2026
Author summary Surface-exposed proteins on bacterial pathogens are enticing candidate vaccine targets, however their exposure to the immune system frequently leads to high levels of antigenic variation, a factor that complicates the development of broadly pro…
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