Signal hierarchical petri nets: Formal semantics of hierarchical regulatory control of biological systems

Source: Plos.org· Eugênio Simão· August 21, 2026
Signal hierarchical petri nets: Formal semantics of hierarchical regulatory control of biological systems

Cellular commitment thresholds—such as metabolite concentrations triggering irreversible developmental transitions—cannot be derived as structural properties of network topology in classical computational formalisms. Existing numerical approaches (e.g., ODE b…

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