Streptomyces-linked exercise gene networks orchestrate immune exclusion and determine immunotherapy response in hepatocellular carcinoma

Source: Plos.org· Xiaoting Zhao, Yu He, Yibin Zhang, Dapeng Liu, Yingwei Wang, Zuopeng Wang, Yudiao Huang· August 20, 2026
Streptomyces-linked exercise gene networks orchestrate immune exclusion and determine immunotherapy response in hepatocellular carcinoma

Exercise-related genes (ERGs) have emerged as potential modulators of tumor biology, yet their systematic characterization in hepatocellular carcinoma (HCC) remains incomplete. Here we integrated 320 ERGs from MSigDB with TCGA-HCC cohort to construct an inter…

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