The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Source: Plos.org· Xiangshu Qiu, Rongguang Lu, Jiaxin Tian, He Zhang, Jiyong Zhou, Mengsi Sun, Xinyu Cao, Xiangyu Zhu, Bocheng Liu, Qihui Yu, Yuanyuan Li, Hualei Wang, Ningyi Jin, Huijun Lu, Ning Shi· July 31, 2026
The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Author summary Getah virus is an emerging mosquito-borne alphavirus. We investigated a naturally occurring substitution in the viral E2 glycoprotein, where histidine at position 86 is replaced by tyrosine. This single change, which we call H86Y, weakened the …

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