Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Source: Plos.org· Nidhi Sharma, Xiaoyun Xie, Renata Szczepaniak, Chitra Rani, Sheida Khojasteh Khosro, Jolanta Krucinska, Xiaoling Chen, Dung Do, Lee Wright, Dennis Wright, Sandra Weller· August 17, 2026
Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Author summary Human herpesviruses are widespread pathogens that establish lifelong infections and can cause severe disease, particularly in immunocompromised individuals, newborns, and older adults. Current antiviral treatments are limited and often target a…

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